A nested case-control study of bladder cancer incidence in a steel manufacturing plant

1998 ◽  
Vol 34 (4) ◽  
pp. 393-398 ◽  
Author(s):  
Katherine Mallin
Keyword(s):  
Bladder Cancer ◽  
Cancer Incidence ◽  
Case Control Study ◽  
Case Control ◽  
Manufacturing Plant ◽  
Steel Manufacturing ◽  
Nested Case Control ◽  
Control Study

The association between allopurinol use and urologic malignancies: A nested case-control study.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 435-435
Author(s):  
Daniel Keizman ◽  
Ido Wolf ◽  
Hadas Dresler ◽  
David Sarid ◽  
Avivit Peer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Bladder Cancer ◽  
Uric Acid ◽  
Cancer Diagnosis ◽  
Case Control Study ◽  
Case Control ◽  
Urologic Malignancies ◽  
Nested Case Control ◽  
Control Study

435 Background: Oxidative stress may be involved in tumorigenesis processes. Uric acid is an important natural antioxidant that may reduce oxidative stress. Allopurinol is a commonly used uric acid lowering agent. There are conflicting data regarding the association between allopurinol use and cancer incidence. In the present nested case control study, we aimed to evaluated the association between allopurinol use and urologic malignancies in a large western population. Methods: conducted a nested case-control study within a population-representative database from the United Kingdom (THIN). Study cases were defined as individuals with any diagnostic code of prostate cancer, bladder cancer, or renal cell carcinoma. For every case, four eligible controls were matched on age, gender, practice site, time of diagnosis, and duration of follow-up. Exposure of interest was any allopurinol use prior to cancer diagnosis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for urologic malignancies were estimated using conditional logistic regression. Adjustment was performed for factors including smoking, BMI, and diabetes. Results: The study population included: for bladder cancer 13440 and 52421 matched controls, prostate cancer 27212 cases and 105940 controls, RCC 1547 cases and 6066 controls. Allopurinol use was associated with a significantly increase of risk for bladder cancer (adjusted OR 1.2, 95%CI 1.09-1.32, p<0.001). prostate cancer (adjusted OR 1.1, 95%CI 1.03-1.,17, p=0.003), RCC (adjusted OR 1.32, 95%CI 1-1..75, p=0.05). In a sensitivity analyses we observed similar associations when alopurinol use was initiated more than two years prior to cancer diagnosis, for bladder cancer (adjusted OR 1.2, 95%CI 1.08-1.33, p=0.001), prostate cancer (adjusted OR 1.09, 95%CI 1.02-1.16, p=0.01), RCC (adjusted OR 1.09, 95%CI 0.78-1.53, p=0.62). Conclusions: Allopurinol use may be associated with an increased risk for urologic malignancies.

scholarly journals The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study

BMJ ◽  
2012 ◽  
Vol 344 (may30 3) ◽  
pp. e3645-e3645 ◽  
Author(s):  
L. Azoulay ◽  
H. Yin ◽  
K. B. Filion ◽  
J. Assayag ◽  
A. Majdan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bladder Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Risk of Bladder Cancer in Diabetic Patients Treated with Rosiglitazone or Pioglitazone: A Nested Case–Control Study

Drug Safety ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. 643-649 ◽  
Author(s):  
Fei-Yuan Hsiao ◽  
Pei-Hua Hsieh ◽  
Weng-Foung Huang ◽  
Yi-Wen Tsai ◽  
Churn-Shiouh Gau
Keyword(s):  
Bladder Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Nested Case Control ◽  
Control Study

scholarly journals 1065Diesel exposure and bladder cancer in contemporary Western Australian miners

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Nita Sodhi-Berry ◽  
Peter Franklin ◽  
Susan Peters ◽  
Alison Reid ◽  
Arthur (Bill) Musk ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
General Population ◽  
Elemental Carbon ◽  
Case Control Study ◽  
Case Control ◽  
Engine Exhaust ◽  
Diesel Engine Exhaust ◽  
Nested Case Control ◽  
Western Australian ◽  
Control Study

Abstract Background Diesel engine exhaust (DEE) is classified as a potential carcinogen for bladder cancer in humans by the International Agency for Research on Cancer. We aimed to compare bladder cancer incidence in Western Australian miners against the general population and determine if there was an association with DEE, measured as Elemental Carbon. Methods A whole-of-population cohort of 218,846 Western Australian miners employed during 1996-2013 was followed-up until June-2017. DEE exposure data was derived from work histories and collated with administrative State-wide cancer and death data. Standardised Incidence Ratios (SIRs) were calculated to compare rates with the general population. A nested case-control study design with matching on attained age was used. Conditional logistic regression was done to calculate Odds Ratios (ORs) for cumulative Elemental Carbon exposure (unlagged and 15-year lagged), after adjusting for smoking pack-years. Results Ninety cases (88 males) were observed and 180,377 controls selected. Miners had lower bladder cancer incidence than the general population (Observed=90; Expected=135.60; SIR:0.66, 95%CI:0.53-0.80). Within miners, DEE exposure was not found to be statistically significantly associated with bladder cancer (unlagged: OR = 0.75, 95%CI: 0.43-1.31; and 15-year lagged: OR = 0.59, 95%CI:0.25-1.40), after adjusting for smoking pack-years (unlagged and lagged OR:1.02, 95%CI:1.01-1.03). Conclusions Miners had lower risk of bladder cancer than the general population. DEE exposure was not associated with bladder cancer in this nested case-control study of contemporary Western Australian miners. Key messages Diesel engine exhaust was not found to be associated with bladder cancer in miners.

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